@article {7348,
	title = {Neurochemical profiling of dopaminergic neurons in the forebrain of a cichlid fish, Astatotilapia burtoni},
	journal = {Journal of Chemical Neuroanatomy},
	volume = {47},
	year = {2013},
	month = {2013///},
	pages = {106 - 115},
	publisher = {Elsevier B.V.},
	abstract = {Across vertebrates, the mesolimbic reward system is a highly conserved neural network that serves to evaluate the salience of environmental stimuli, with dopamine as the neurotransmitter most relevant to its function. Although brain regions in the dopaminergic reward system have been well characterized in mammals, homologizing these brain areas with structures in teleosts has been controversial, especially for the mesencephalo-diencephalic dopaminergic cell populations. Here we examine the neurochemical profile of five dopaminergic cell groups (Vc, POA, PPr, TPp, pTn) in the model cichlid Astatotilapia burtoni to better understand putative homology relationships between teleosts and mammals. We characterized in the adult brain the expression patterns of three genes (etv5, nr4a2, and pitx3) that either specify dopaminergic cell fate or maintain dopaminergic cell populations. We then determined whether these genes are expressed in dopaminergic cells. We find many striking similarities in these gene expression profiles between dopaminergic cell populations in teleosts and their putative mammalian homologs. Our results suggest that many of these dopaminergic cell groups are indeed evolutionarily ancient and conserved across vertebrates. ?? 2013 Elsevier B.V.},
	keywords = {dopamine, Etv5, Nr4a2, Nurr1, Pitx3, Tyrosine hydroxylase, Ventral tegmental area},
	url = {http://dx.doi.org/10.1016/j.jchemneu.2012.12.007},
	author = {O{\textquoteright}Connell, Lauren A. and Fontenot, Miles R. and Hofmann, Hans A.}
}
