@article {9370,
	title = {Extensive gene content variation in theBrachypodium distachyon pan-genome correlateswith population structure},
	journal = {Nature Communications},
	number = {2184},
	year = {2017},
	pages = {doi:10.1038/s41467-017-02292-8},
	abstract = {While prokaryotic pan-genomes have been shown to contain many more genes than any individual organism, the prevalence and functional significance of differentially present genes in eukaryotes remains poorly understood. Whole-genome de novo assembly and annotation of 54 lines of the grass Brachypodium distachyon yield a pan-genome containing nearly twice the number of genes found in any individual genome. Genes present in all lines are enriched for essential biological functions, while genes present in only some lines are enriched for conditionally beneficial functions (e.g., defense and development), display faster evolutionary rates, lie closer to transposable elements and are less likely to be syntenic with orthologous genes in other grasses. Our data suggest that differentially present genes contribute substantially to phenotypic variation within a eukaryote species, these genes have a major influence in population genetics, and transposable elements play a key role in pan-genome evolution.},
	url = {https://www.nature.com/articles/s41467-017-02292-8},
	author = {Gordon, Sean P and Contreras-Moreira, Bruno and Woods, Daniel P and Des Marais, David L and Burgess, Diane and Shu, Shengqiang and Stritt, Christopher and Roulin, Anne C and Schackwitz, Wendy and Tyler, Ludmila and Martin, Joel and Lipzen, Anna and Dochy, Niklas and Phillips, Jeremy and Barry, Kerrie and Geuten, Koen and Budak, Hikmet and Juenger, Thomas E and Amasino, Richard and Caicedo, Ana L and Goodstein, David and Davidson, Patrick and Mur, Luis A. J. and Figueroa, Melania and Freeling, Michael and Catalan, Pilar and Vogel, John P}
}
