@article {16621,
	title = {Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2},
	journal = {Nature Cell Biology},
	volume = {25},
	year = {2023},
	pages = {592{\textendash}603},
	abstract = {Cells respond to perturbations such as inflammation by sensing changes in metabolite levels. Especially prominent is arginine, which has known connections to the inflammatory response. Aminoacyl-tRNA synthetases, enzymes that catalyse the first step of protein synthesis, can also mediate cell signalling. Here we show that depletion of arginine during inflammation decreased levels of nuclear-localized arginyl-tRNA synthetase (ArgRS). Surprisingly, we found that nuclear ArgRS interacts and co-localizes with serine/arginine repetitive matrix protein 2 (SRRM2), a spliceosomal and nuclear speckle protein, and that decreased levels of nuclear ArgRS correlated with changes in condensate-like nuclear trafficking of SRRM2 and splice-site usage in certain genes. These splice-site usage changes cumulated in the synthesis of different protein isoforms that altered cellular metabolism and peptide presentation to immune cells. Our findings uncover a mechanism whereby an aminoacyl-tRNA synthetase cognate to a key amino acid that is metabolically controlled during inflammation modulates the splicing machinery.},
	url = {https://www.nature.com/articles/s41556-023-01118-8},
	author = {Cui, H and Diedrich, JK and Wu, DC and Lim, JJ and Nottingham, RM and Moresco, JJ and Yates, JR and Blencowe, BJ and Lambowitz, A M and Schimmel, P}
}
