@article {417,
	title = {The Mauriceville plasmid reverse transcriptase can initiate cDNA synthesis de novo and may be related to reverse transcriptase and DNA polymerase progenitor.},
	journal = {Cell},
	volume = {75},
	number = {6},
	year = {1993},
	month = {1993 Dec 17},
	pages = {1071-81},
	abstract = {We show that the reverse transcriptase (RT) encoded by the Mauriceville mitochondrial plasmid of Neurospora closely resembles viral RNA-dependent RNA polymerases in initiating cDNA synthesis opposite the penultimate C residue of a 3{\textquoteright} tRNA-like structure and has the unprecedented ability for a DNA polymerase to initiate DNA synthesis at a specific site in a natural template without a primer. The Mauriceville plasmid enzyme can also use DNA or RNA primers in a manner suggesting how a primitive RT could have evolved from an RNA-dependent RNA polymerase into retroviral and other types of RTs. The characteristics of the Mauriceville plasmid RT suggest that it may be related to the progenitor of present-day RTs and DNA polymerases.},
	keywords = {Base Sequence, Cloning, Molecular, DNA Replication, DNA, Complementary, DNA, Fungal, DNA-Directed DNA Polymerase, Mitochondria, Molecular Sequence Data, Neurospora crassa, Oligodeoxyribonucleotides, Plasmids, Polymerase Chain Reaction, RNA-Directed DNA Polymerase},
	issn = {0092-8674},
	author = {Wang, H and Lambowitz, A M}
}
