May 2023
Role of apyrase in salvaging of phosphate from extracellular nucleotides and in regulating phosphate uptake in Arabidopsis. .” Preprint of article submitted. Abstract
. “ Apyrases are NTPDases that remove the terminal phosphate from NTPs and NDPs, but not from NMPs. They have conserved structures and functions in yeast, plants and animals. Among the most studied APYs in plants are those in Arabidopsis (AtAPYs) and peas (PsAPYs), both of which have been shown to play major roles in regulating plant growth and development. Valuable insights on their functional roles have been gained by transgenically altering their transcript abundance, either by constitutively expressing them or by their suppression. This review focuses on studies of transgenic lines of yeast and multiple different plants that revealed insights on the growth-altering functions of plant apyrases in different organisms. APY expression can also be inhibited post-translationally by chemically blocking its enzymatic activity, so this review also briefly covers studies that used inhibitors to suppress APY activity in plants and fungi.