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The Payne Lab

Focus on Shigella and Vibrio species

The Payne Lab
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    Our studies focus on the genetics and regulation of iron acquisition systems and other virulence factors of the intestinal pathogens Shigella flexneri and Vibrio cholerae. Our work combines biochemistry and genetics to determine how the essential metals iron and manganese are transported and utilized in V. cholerae and S. flexneri. Iron transport systems are of particular interest to us because iron acquisition in the human host is critical to microbial virulence. Specifically we are studying the bacterial Feo system for ferrous iron transport. Additionally, we use in vitro models combined, such as enteroids, with genetic analyses to determine the role of host lipids and carbon metabolism in the pathogenesis of S. flexneri. Regarding S. flexneri, we also examine interspecies interactions between S. flexneri and normal members of human gut microbiota to determine how they  influence in S. flexneri growth and virulence. Finally, we are also exploring the environmental regulation of critical virulence factors by the RNA binding protein CsrA in V. cholerae.

    Learn more about our research here.

     

Recent Publications

  • Vibrio cholerae CsrA directly regulates varA to increase expression of the three nonredundant Csr sRNAs
  • Developing Colorimetric and Luminescence-Based High-Throughput Screening Platforms for Monitoring the GTPase Activity of Ferrous Iron Transport Protein B (FeoB)
  • Vibrio cholerae Alkalizes Its Environment via Citrate Metabolism to Inhibit Enteric Growth In Vitro
  • Bacteroides thetaiotaomicron Outer Membrane Vesicles Modulate Virulence of Shigella flexneri
  • Disentangling the Evolutionary History of Feo, the Major Ferrous Iron Transport System in Bacteria
  • Iron Transport and Metabolism in Escherichia, Shigella, and Salmonella
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University of Texas, College of Natural Sciences

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