Publications

2020

66. Lucas, M. J.; Pan, H. S.; Verbeke E. J.; Webb, L. J.;* Taylor, D.;* Keitz, B. K.* “Functionalized Mesoporous Silicas Direct Structural Polymorphism of Amyloid-b Fibrils.” Langmuir 2020, In Revision. *Co-corresponding authors.

65. Webb, L. J.; Cho, M. et al. “Vibrational Frequency Map, Vibrational Spectroscopy, and Intermolecular Interaction.” Chem. Rev. 2020, In Revision.

64. Crittenden, C. M.; Novelli, E. T.; Xu, G.; Giles, D. H.; Fies, W. A.; Mehaffey, R.; Dalby, K.; Webb, L. J.; Brodbelt, J. S. “Structural Evaluation of Protein/Metal Complexes via Native Electrospray Ultraviolet Photodissociation Mass Spectrometry.” J. Am. Soc. Mass Spectr. 2020, In Press.

63. Novelli, E.; First, J. T.; Webb, L. J. “Beyond pKa: Experiments and Simulations of Nitrile Vibrational Probes in Staphylococcal Nuclease Show the Importance of Local Interactions.” J. Phys. Chem. B 2020, 124, 16, 3387-3399, DOI: 10.1021/acs.jpcb.0c00747

62. Fies, W. A.; First, J. T.; Dugger, J. W.; Doucet, M.; Browning, J. F.; Webb, L. J. “Quantifying the Extent of Hydration of a Surface-Bound Peptide using Neutron Reflectometry.” Langmuir 2020, 36, 2 637-649 DOI: 10.1021/acs.langmuir.9b02559.

2019

61. Mehaffey, R. M.; Schardon, C.; Novelli, E.; Cammarata, M.; Webb, L. J.; Fast, W.; Brodbelt, J. S. “Investigation of GTP-Dependent Dimerization of G12X K-Ras Variants Using Ultraviolet Photodissociation Mass Spectrometry.” Chem. Sci. 2019, DOI: 10.1039/c9sc01032g.

60. Fathizadeh, A.; Kogan, M.; Anderson, C.; Webb, L. J.; Elber, R. “Defect Assisted Permeation Through a Phospholipid Membrane: Experimental and Computational Study of the Peptide WKW.” J. Phys. Chem. B 2019, 123, 6792-6798. DOI: 10.1021/acs.jpcb.9b05414

59. First, J. T.; Webb, L. J. “Agreement between Experimental and Simulated Circular Dichroic Spectra of a Positively Charged Peptide in Aqueous Solution and on Self-Assembled Monolayers.” J. Phys. Chem. B 2019, 123, 4512-4526, DOI: 10.1021/acs.jpcb.9b02102

58.  Fies, W. A.; Dugger, J. W.; Dick, J. E.; Wilder, L.; Browning, K.; Doucet, M.; Browning, J. F.; Webb, L. J.  "Water Permeation in Submerged Self-Assembled Monolayers on Gold Observed with Neutron Reflectometry."  Langmuir 201933, 5647-5662, DOI: 10.1021/acs.langmuir.9b02559

57.  Cardenas, A. E.; Anderson, C. M.; Elber, R.; Webb, L. J.  "Partition of Positively and Negatively Charged Tryptophan Ions in Membranes with Inverted Phospholipid Heads: Simulations and Experiments." J. Phys. Chem. B 2019123, 3272-3281, DOI: 10.1021/acs.jpcb.9b00754

56.  Wilder, L; Fies, W. A.; Rabin, C.; Webb, L. J.; Crooks, R. M.; "Conjugation of alpha-Helical Peptides to the Surface of Gold Nanoparticles." Langmuir 201935, 3363-3371, DOI: 10.1021/acs.langmuir.9b00075

55.  Anderson, C. M.; Cardenas, A.; Elber, R.; Webb, L. J. " Preferential Equilibrium Partitioning of Positively Charged Tryptophan into Phosphatidylcholine Bilayer Membranes. J. Phys. Chem. B 2019123, 170-179, DOI: 10.1021/acs.jpcb.8b09872

2018

54.  Novelli, E. T.; First, J. T.; Webb, L. J. "Quantitative Measurement of Intrinsic GTP Hydrolysis for Carcinogenic Glutamine 61 Mutants in H-Ras." Biochemistry 2018, 57, 6356-6366, DOI: 10.1021/acs.biochem.8b00878

53.  First, J. T.; Slocum, J. D.; Webb, L. J.  "Quantifying the Effects of Hydrogen Bonding on Nitrile Frequencies in GFP: Beyond Solvent Exposure." J. Phys. Chem. B 2018122, 6735-6743, DOI: 10.1021/acs.jpcb.8b03907

52.  Slocum, J. D.; Webb, L. J. "Measuring Electric Fields in Biological Matter Using the Vibrational Stark Effect of Nitrile Probes." Ann. Rev. Phys. Chem201869, 253-271, DOI: 10.1146/annurev-physchem-052516-045011

2017

51.  Slocum, J. D.; First, J. T.; Webb, L. J.  "Orthogonal Electric Field Measurements Near the Green Fluorescent Protein Fluorophore Through Stark Spectroscopy and pKa Shifts Provide a Unique Benchmark for Electrostatics Models." J. Phys. Chem. B 2017121, 6799-6812, DOI: 10.1021/acs.jpcb.7b03935

50.  Slocum, J. D.; Webb, L. J.  "A Double Decarboxylation in Superfolder Green Fluorescent Protein Leads to High Contrast Photoactivation." J. Phys. Chem. Lett. 20178, 2862-2868, DOI: 10.1021/acs.jpclett.7b01101

49.  Blasiak, B.; Londergan, C. H.; Webb, L. J.; Cho, M.  "Vibrational Probes: From Small Molecule Solvatochromism Experiments to Applications in Complex Systems."  Acc. Chem. Res. 201750, 968-976, DOI: 10.1021/acs.accounts.7b00002

48.  Shrestha, R.; Anderson, C. M.; Cardenas, A. E.; Elber, R.; Webb, L. J.  "Direct Measurement of the Effect of Cholesterol and 6-Ketocholestanol on Membrane Dipole Field Using Vibrational Stark Effect Spectroscopy Coupled with Molecular Dynamics Simulations." J. Phys. Chem. B 2017121, 3424-3436, DOI: 10.1021/acs.jpcb.6b09007

2016

47.  Raigoza, A. F.; Onyirioha, K.; Webb, L. J.  "Controlling Noncovalent Interactions Between a Lysine-Rich alpha-Helical Peptide and Self-Assembled Monolayers of Alkanethiols on Au through Functional Group Diversity." Appl. Surf. Sci. 2016396, 1831-1839, DOI: 10.1016/j.apsusc.2016.11.177

46.  Raigoza, A. F.; Fies, W.; Lim, A.; Onyirioha, K.; Webb, L. J.  "One-Pot Reaction for the Preparation of Biofunctionalized Self-Assembled Monolayers on Gold Surfaces." Appl. Surf. Sci. 2016394, 288-296, DOI: 10.1016/j.apsusc.2016.10.036

45.  Blasiak, B.; Ritchie, A. W.; Webb, L. J.; Cho, M.  "Vibrational Solvatochromism of Nitrile Infrared Probes: Beyond Vibrational Stark Dipole Approach."  Phys. Chem. Chem. Phys. 201618, 18094-18111, DOI: 10.1039/C6CP01578F
 
44.  Slocum, J. D.; Webb, L. J.  "Nitrile Probes of Electric Field Agree with Independently Measured Fields in GFP Even in the Presence of Hydrogen Bonding."  J. Am. Chem. Soc. 2016138, 6561-6570, DOI: 
10.1021/jacs.6b02156

2015

43.  Lebegue, E.; Anderson, C. M.; Dick, J. E.; Webb, L. J.; Bard, A.  "Electrochemical Detection of Single Phospholipid Vesicle Collisions at a Pt Ultramicroelectrode."  Langmuir 201531, 11734-11739, DOI: 10.1021/acs.langmuir.5b03123
 
42.  Ritchie, A. R.; Webb, L. J.  "Understanding and Manipulating Electrostatic Fields at the Protein-Protein Interface Using Vibrational Spectroscopy and Continuum Electrostatics Calculations."  J. Phys. Chem B 2015119, 13945-13957, DOI: 10.1021/acs.jpcb.5b06888

41.  Schroder, K.; Alvarado, J.; Yersak, T.; Li, J.; Dudney, N.; Webb, L. J.;* Meng, Y. S.;* Stevenson, K. S.*  "The Effect of Fluoroethylene Carbonate as an Additive on the Solid Electrolyte Interphase on Silicon Lithium-Ion Electrodes."  Chem. Matter. 201527, 5531-5542, DOI: 10.1021/acs.chemmater.5b01627
*Co-Corresponding Authors

40.  Schroder, K. W.; Dylla, A. G.; Bishop, L. D. C.; Kamilar, E. R.; Saunders, J.; Webb, L. J.;* Stevenson, K. S.*  "The Effects of Solute-Solvent Hydrogen Bonding on Non-Aqueous Electrolyte Structure."  J. Phys. Chem. Lett. 2015, 6, 2888-2891, DOI: 10.1021/acs.jpclett.5b01216
*Co-Corresponding Authors

39.  Dugger, J. W.; Webb, L. J.  "Preparation and Characterization of Biofunctionalized Inorganic Surfaces."  Langmuir 2015, 31, 10331-10340, DOI: 10.1021/acs.langmuir.5b01876
  
38.  Cardenas, A. E.; Shrestha, R.; Webb, L. J.; Elber, R.  "Membrane Permeation of a Peptide: It is Better to be Positive."  J. Phys. Chem. B, 2015119, 6412-6420, DOI: 10.1021/acs.jpcb.5b02122

37.  Dugger, J. W.; Webb, L. J.  "Fibrillar Structures Formed by Covalently-Bound Short Beta-Stranded Peptides on Self-Assembled Monolayers."  Langmuir 2015, 31, 3441-3450, DOI: 10.1021/la5049369

36.  Shrestha, R.; Cardenas, A. E.; Elber, R. Webb, L. J.  "Measurement of the Membrane Dipole Electric Field in DMPC Vesicles Using Vibrational Shifts of p-Cyanophenylalanine and Molecular Dynamics Simulations."  J. Phys. ChemB 2015, 119, 2869-2876, DOI: 10.1021/jp511677j

2010 - 2014

35.  Schroder, K.; Dylla, A.; Harris, S.;  Webb, L. J.;* Stevenson, K. S.*  "The Role of Surface Oxide in the Formation of Solid Electrolyte Interphases at Silicon Electrodes for Lithium-ion Batteries."  ACS Appl. Mater. Interface.  20146, 21510-21524, DOI: 10.1021/am506517j
*Co-Corresponding Authors

34.  Walker, D. M.; Wang, R.; and Webb, L. J.  "Conserved Electrostatic Fields at the Ras-Effector Interface Measured Through Vibrational Stark Effect Spectroscopy Explain the Difference in Tilt Angle in the Ras Binding Domain of Raf and RalGDS."  Phys. Chem. Chem. Phys.  201416. 20047-20060, DOI: 
10.1039/C4CP00743C

33.  Lim, M.; Wu, J.; Yao, J.; Gallardo, I. F.; Dugger, J. W.; Webb, L. J.; Huang, J.; Salmi, M. L.; Clark, G.; Roux, S. J.  "Apyrase Suppression Raises Extracellular ATP Levels and Induces Gene Expression and Cell Wall Changes Characteristic of Stress Responses."  Plant Phys2014164, 2054-2067, DOI: 10.1104/pp.113.233429


32.  Ritchie, A. R.; and Webb, L. J.  "Optimizing Electrostatic Field Calculations with the Adaptive Poisson-Boltzmann Solver to PRedict Electric Fields at Protein-Protein Interfaces II: Explicit Near-Probe and Hydrogen Bonding Water Molecules."  J. Phys. Chem. B 2014118, 7692-7702, DOI: 10.1021/jp4092656

31.  Ritchie, A. W. and Webb, L. J.  "Optimizing Electrostatic Field Calculations with the Adaptive Poisson-Boltzmann Solver to Predict Electric Fields at Protein-Protein Interfaces I: Sampling and Focusing."  J. Phys. Chem. B 2013117, 11473-11489, DOI: 10.1021/jp404582w

30.  Raigoza, A. F.; Dugger, J. W.; and Webb, L. J.  "Review: Recent Advances and Current Challenges in Scanning Probe Microscopy of Biomolecular Surfaces and Interfaces."  ACS Appl. Mater. Interface. 20135, 9249-9261, DOI: 10.1021/am4018048
 
29.  Gupta, S. C.; Sung, B.; Prasad, S.; Webb, L. J.; and Aggarwal, B. B.  "Exploring the Anti-Cancer Potential of Non-Cancer Drugs: Teaching New Tricks to Old Dogs."  Trends Pharmacol. Sci201334, 508-517, DOI: 
10.1016/j.tips.2013.06.005

28.  Walker, D. M.; Hayes, E. C.; and Webb, L. J.  "Vibrational Stark Effect Spectroscopy Reveals Complementary Electrostatic Fields Created by Protein-Protein Binding at the Interface of Ras and Ral."  Phys. Chem. Chem. Phys201315, 12241-12252, DOI: 10.1039/C3CP51284C
 
27.  Raigoza, A. F. and Webb, L. J.  "Molecularly Resolved Images of Peptide-Functionalized Gold Surfaces by Scanning Tunneling Microscopy."  J. Am. Chem. Soc. 2012, 134, 19354-19357, DOI: 
10.1021/ja309632m

26.  Schroder, K.; Celio, H.; Webb, L. J.;* Stevenson, K. S.*  "Examining Solid Electrolyte Interphase Formation on Crystalline Silicon Electrodes: Influence of Electrochemical Preparation and Ambient Exposure Conditions.  J. Phys. Chem. C  2012, 116, 19737-19747, DOI10.1021/jp307372m
*Co-corresponding authors.

25.  Ragain, C. M.; Newberry, R. W.; Ritchie, A. W.; Webb, L. J.  "The Role of Electrostatics in Differential Binding of RalGDS to Rap Mutations E30D and K31E Investigated by Vibrational Spectroscopy of Thiocyanate Probes."  J. Phys. Chem. B 2012, 116, 9326-9336, DOI: 
10.1021/jp303272y

24.  Stafford, A. J.; Walker, D.; Webb, L. J.  Electrostatic Effects of Mutations to Ras Glutamine 61 Measured Using Vibrational Spectroscopy of a Thiocyanate Probe."  Biochemistry 2012, 51, 2757-2767, DOI: 10.1021/bi201225p

23.  Gallardo, I. F. and Webb, L. J.  "Demonstration of alpha-Helical Structure of Peptides Tethered to Gold Surfaces Using Surface Infrared and Circular Dichroic Spectroscopies."  Langmuir 2012, 28, 3510-3515, DOI: doi.org/10.1021/la204927q

22.  Gupta, S. C.; Prasad, S.; Kim, J. H.; Patchva, S.  Webb, L. J.; Priyadarsini, I. K.; Aggarwal, B. B.  "Multitargeting by Curcumin as Revealed by Molecular Interaction Studies."  Nat. Prod. Rep. 2011, 28, 1937-1955, DOI: 10.1039/C1NP00051A

21.  Hu, W. and Webb, L. J.  "Direct Measurement of the Membrane Dipole Field in Bicelles Using Vibrational Stark Effect Spectroscopy."  J. Phys. Chem. Lett 2011, 2, 1925-1930, DOI: 10.1021/jz200729a

20. Ensign, D.L. and Webb, L. J.  "Factors Determining Electrostatic Fields at the Ras/Effector Interface."  Proteins 2011, 79, 3511-3524, DOI: 10.1002/prot.23095

19. Gallardo, I. F. and Webb, L. J.  "Tethering Hydrophobic Peptides to Functionalized Self-Assembled Monolayers on Gold Through Two Chemical Linkers Using the Huisgen Cycloaddition."  Langmuir 2010,  26, 18959-18966, DOI: 10.1021/la1036585

18. Stafford, A. J.; Ensign, D. L.; and Webb, L. J.  "Vibrational Stark Effect Spectroscopy at the Interface of Ras and Rap1A Bound to the Ras Binding Domain of RalGDS Reveals an Electrostatic Mechanism for Protein-Protein Interaction."  J. Phys. Chem. B 2010, 114, 15331-15344, DOI: 10.1021/jp106974e

< 2010

17. Webb, L. J.; Boxer, S. G.  "Electrostatic Fields Near the Active Site of Human Aldose Reductase: 1. New Inhibitors and Vibrational Stark Effect Measurements."  Biochemistry 2008, 47, 1588-1598.  pdf

16. Fafarman, A. T.; Webb, L. J.; Chuang, J. I.; Boxer, S. G.  "Site-Specific Conversion of Cysteine Thiols into Thiocyanate Creates an IR Probe for Electric Fields in Proteins."  J. Am. Chem. Soc. 2006, 128, 13356-13357.  pdf

15. Traub, M. C.; Biteen, J. S.; Michalak, D. J.; Webb, L. J.; Brunschwig, B. S.; Lewis, N. S.  "Phosphine Functionalization of GaAs(111)A Surfaces."  J. Phys. Chem. C 2008, 112, 18467-18473.  pdf

14. Jaeckel, B.; Hunger, R.; Webb, L. J.; Jaegermann, W.; Lewis, N. S.  "High-Resolution Synchrotron Photoemission Studies of the Electronic Structure and Thermal Stability of CH3- and C2H5-Functionalized Si(111) Surfaces." J. Phys. Chem. C 2007, 111, 18204-18213.  pdf

13. Hunger, R.; Fritsche, R.; Jaechel, B.; Webb, L. J.; Jaegermann, W.; Lewis, N. S.  "High-Resolution Photoemission Studies of the Interfacial Reactivity and Interfacial Energetics of Au and Cu Schottky Barriers on Methyl-Terminated Si(111) Surfaces."  Surf. Sci. 2007, 601, 2896-2907.  pdf

12. Nemanick, E. J.; Hurley, P. T.; Webb. L. J.; Knapp, D. W.; Michalak, D. J.; Brunschwig, B. S.; Lewis, N. S.  "Chemical and Electrical Passivation of Single-Crystal Silicon(100) Surfaces through a Two-Step Chlorination/Alkylation Process."  J. Phys. Chem. B 2006, 110, 14770-14778.  pdf

11. Traub, M. C.; Biteen, J. S.; Michalak, D. J.; Webb, L. J.; Brunschwig, B. S.; Lewis, N. S.  "High-Resolution X-ray Photoelectron Spectroscopy of Chlorine-Terminated GaAs(111)A Surfaces."  J. Phys. Chem. B 2006, 110, 15641-15644.  pdf

10. Yu, H.; Webb, L. J.; Solares, S. D.; Cao, P.; Goddard, W. A.; Heath, J. R.; Lewis, N. S.  "Scanning Tunneling Microscopy of Ethylated Si(111) Surfaces Prepared by a Chlorination / Alkylation Process."  J. Phys. Chem. B 2006, 110, 23898-23903.  pdf

9. Yu, H.; Webb, L. J.; Heath, J. R.; Lewis, N. S.  "Scanning Tunneling Spectroscopy of Methyl- and Ethyl-Terminated Si(111) Surfaces."  Appl. Phys. Lett. 2006, 88, 252111-1-252111-3.  pdf

8. Webb, L. J.; Rivillon, S.; Michalak, D. J.; Chabal, Y. J.; Lewis, N. S.  "Transmission Infrared Spectroscopy of Methyl- and Ethyl-Terminated Silion(111) Surfaces."  J. Phys. Chem. B 2006, 110, 7349-7356.  pdf

7. Webb, L. J.; Michalak, D. J.; Biteen, J. S.; Brunschwig, B. S.; Chan, A. S. Y.; Knapp, D. W.; Meyer, J. M.; Nemanick, E. J.; Traub, M. C.; Lewis, N. S.  "High-Resolution Soft X-ray Photoelectron Spectroscopic Studies and Scanning Auger Microscopy Studies of the Air Oxidation of Alkylated Silicon(111) Surfaces."  J. Phys. Chem. B 2006, 110, 23450-23459.  pdf
 
6. Solares, S. D.; Yu, H.; Webb, L. J.; Lewis, N. S.; Heath, J. R.; Goddard, W. G.  "Chlorination - Methylation of the Hydrogen-Terminated Silicon(111) Surface Can Induce a Stacking Fault in the Presence of Etch Pits."  J. Am. Chem. Soc. 2006, 128, 3850-3851.  pdf

5. Hunger, R.; Fritsche, R.; Jaechel, B.; Jaegermann, W.; Webb, L. J.; Lewis, N. S.  "Chemical and Electronic Characterizaiton of Methyl-Terminated Si(111) Surfaces by High-Resolution Synchrotron Photoelectron Spectroscopy."  Phys. Rev. B 2005, 72, 045317-7.  pdf

4. Rivillon, S.; Chabal, Y. J.; Webb, L. J.; Michalak, D. J.; Lewis, N. S.; Halls, M. D.; Raghavachari, K.  "Infrared Spectroscopy of Chlorine-Terminated Si(111) Surfaces."  J. Vac. Sci. Technol. 2005, 23, 1100-1106.  pdf

3. Webb, L. J.; Nemanick, E. J.; Biteen, J. S.; Knapp, D. W.; Michalak, D. J.; Traub, M. C.; Chan, A. S. Y.; Brunschwig, B. S.; Lewis, N. S.  "High-Resolution X-ray Photoelectron Spectroscopic Studies of Alkylated Crystalline Silicon(111) Surfaces."  J. Phys. Chem. B 2005, 109, 3930-3937.  pdf

2. Yu, H.; Webb, L. J.; Reis, R.; Solares, S. D.; Goddard, W. A.; Heath, J. R.; Lewis, N. S.  "Low Temperature STM Images of Methyl-Terminated Si(111) Surfaces."  J. Phys. Chem. B 2005, 109, 671-674.  pdf

1. Webb, L. J.; Lewis, N. S.  "Comparison of the Electrical Properties and Chemical Stability of Crystalline Silicon(111) Surfaces Alkylated Using Grignard Reagents or Olefins with Lewis Acid Catalysts."  J. Phys. Chem. B 2003, 107, 5404-5412.  pdf

Webb, L. J.  Chemical Characterization and Charge Carrier Dynamics of Crystalline Silicon(111) Surfaces Modified with Surface-Bound Organic Functional Groups.  California Institute of Technology, 2005.  pdf