Harshey Lab Twitter

  • NAChristakis
    NAChristakis I stand with ⁦⁦@JonHaidt⁩ against this sort of mandate. He is resigning from Society for Personality & Social Psychology given new requirement that everybody presenting research explain how their work advances "equity, inclusion, and anti-racism." t.co/zhDVcRcheA
  • harsheylab
    harsheylab Finally, motility plays an important role in assisting the mutator phenotype to 'surf' to the edge. A 'phenotype surfing' model is proposed, explaining why chances of survival of even unfit mutants are high at the edge due to decreased competition / increased genetic drift. End
  • harsheylab
    harsheylab Fifth, high efflux produces high ROS and cell death, which releases a 'necrosignal' that stimulates efflux. Thus, the cycle of efflux - ROS - cell death - necrosignaling - more efflux, contributes to the accelerated evolution. 4/
  • harsheylab
    harsheylab Third, this link was validated experimentally in the lab and corroborated in the real world by examining a clinical 'resistome' database. Fourth, inhibitors that target efflux decrease evolvability to antibiotic resistance. 3/
  • harsheylab
    harsheylab First, cells at the edge are engaged in high-efflux, likely to obtain iron. Second, there is a genetic link between high efflux pump activity and downregulation of specific DNA repair genes in the MMR and BER pathways, producing the mutator phenotype. 2/
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