About The Sullivan Lab
The discovery of silencing non-coding RNAs has dramatically changed our understanding of the regulation of gene expression. This has opened up a new area in the regulation of the immune response. The Sullivan Lab's research focuses on understanding the role of non-coding RNAs in virus infection and host defense pathways. Researchers work with an array of diverse virus families including DNA tumor viruses and RNA viruses, as well as the enzyme DUSP11. DUSP11 is an RNA phosphatase that helps to regulate the innate immune response. The Sullivan Lab's goals are several-fold:
- To understand the functions of viral and host-encoded non-coding RNAs and how they contribute to viral lifecycle and pathogenesis
- To explore the functions and regulation of immunogenic non-coding RNAs
- To uncover new mechanisms of gene regulation utilized by viruses and the host
- To use viruses as "molecular divining rods" to probe for new classes of host defense pathways.
2023 Research
- Cao P, Fleming D, Moustafa DA, Dolan SK, Szymanik KH, Redman WK, Ramos A, Diggle FL, Sullivan CS, Goldberg JB, Rumbaugh KP, Whiteley M. A Pseudomonas aeruginosa small RNA regulates chronic and acute infection. Nature. 2023 May 24. Epub ahead of print. PMID: 37225987.
2022 Research
- Blois S, Goetz BM, Bull JJ, Sullivan CS. Interpreting and de-noising genetically engineered barcodes in a DNA virus. PLoS Comput Biol. 2022 Nov 22;18(11):e1010131. Epub ahead of print. PMID: 36413582.
2021 Research
- R Yang, EE Lee, J Kim, JH Choi, E Kolitz, ... CS Sullivan. 5/17/2021. Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus. PLOS Pathogens. May 17, 2021.
- JH Choi and CS Sullivan. DUSP11 and triphosphate RNA balance during virus infection. PLOS Pathogens. January 14, 2021.
2020 Research
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R Yang, E Lee, J Kim, JH Choi, C Crewe, PE Scherer, E Kolitz, C Cockerell, TR Smith, L Rosen, L Verlinden, MC Feltkamp, CS Sullivan, and RC Wang. Human Polyomavirus-Encoded Circular RNAs. BioRxiv. Preprint. December 22, 2020.
- JH Choi, JM Burke, KH Szymanik, U Nepal, A Battenhouse, JT Lau, A Stark, V Lam, and CS Sullivan. DUSP11-mediated control of 5′ -triphosphate RNA regulates RIG-I sensitivity. Genes & Dev. November 12, 2020.
- KB Ragan, S Bhadra, JH Choi, D Towers, CS Sullivan and AD Ellington.Comparison of media and standards for SARS-CoV-2 RT-qPCR without prior RNA preparation. medRxiv. Preprint. September 17, 2020.