Zhang Lab at UT Austin

Welcome to Zhang Lab!

Mission

Free thinking

Ethical practice

Team work

Enjoy science

Austin

Recent Publications

Insights into the Main Protease of SARS-CoV-2: Thermodynamic Analysis, Structural Characterization, and the Impact of Inhibitors
Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription
In vitro reconstruction of site-specifically phosphorylated RNA Polymerase II to identify the recruitment of novel transcription regulators
Thr4 phosphorylation on RNA Pol II occurs at early transcription regulating 3’-end processing
Evolving Dual-Trait EPSP Synthase Variants Using a Synthetic Yeast Selection System

Welcome Statement

Phantom of opera

The Zhang Lab is dedicated to unraveling the fascinating realm of post-translational modifications and its effects on eukaryotic transcription. We focus on phosphorylation utilizing cutting-edge approaches that merge structural biology, biophysics, and Nextgen sequencing. Our aim is to shed light on the complexities of kinases, phosphatases, and transcription factors involving in diseases like glioblastoma and neurodegenerative diseases. Moreover, we believe that through our structural understanding, we can make a real impact by designing small molecules or proteins that can modulate enzymatic activities. Join us in this meaningful quest for knowledge.