In Press
(90), E. E. Escobar, W Yang, M. B. Lanzillotti, K.J. Juetten, S Shields, D. Siegel, Y. J. Zhang, and J.S. Brodbelt. “Tracking Inhibition of human Small C-terminal Domain Phosphatase 1 using 193 nm Ultraviolet Photodissociation Mass Spectrometry.” Journal of the American Society for Mass Spectrometry .
(89), Miller LG, Kim W, Schowe S, Taylor K, Han R, Jain V, Park R, Sherman M, Fang J, Ramirez H, Ellington AD, Tamamis P, Resendiz MJE, Y. J. Zhang (co-corresponding), and Contreras L. “Selective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation.” PNAS.
(88), Panina SB, Schweer JV, Zhang Q, Raina G, Hardtke HA, Kim S, Yang WJ, Siegel D, and Zhang YJ. “Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells.” BMC Biology, 22, 83. Publisher's Version
(87), I Wallach, A Morrison, .., .., B Medellin, .., .., Y. Jessie Zhang, .., and A Heifets. “AI is a Viable Alternative to High Throughput Screening: a 318-Target Study.” Scientific Reports, 14, Pp. 7526. Publisher's Version
(86), S d’Oelsnitz, D Diaz, W Kim, D Acosta, M Schechter, M Minus, J Howard, H Do, T Dangerfield, J Loy, HS Alper, YJ Zhang, and AD Ellington. “Synthetic microbial sensing and biosynthesis of a branchpoint amaryllidaceae alkaloid.” Nature Communication, 15, Pp. 2084 (2024) . Publisher's Version
(85), HA Hardtke, and YJ Zhang. “Collaborators or competitors: The communication between RNA polymerase II and the nucleosome during eukaryotic transcription.” Critical Reviews in Biochemistry and Molecular Biology. Publisher's Version
(83), R.Y. Moreno, K.J. Juetten, S.B. Panina, J.P. Butalewicz, B.M. Floyd, M.K. Venkat Ramani, E.M. Marcotte, J.S. Brodbelt, and Y. J. Zhang. “Distinctive Interactomes of RNA polymerase II phosphorylation during different stages of transcription.” iScience, 26, 9. Publisher's Version
(82), Erwin, K., R.Y. * Moreno, B-J. Baas, Y. J Zhang (co-corresponding), and C.P. Whitman. “Evolution of the fused 4-oxalocrotonate Tautomerase in the Tautomerase Superfamily: Introduction of Asymmetry.” Biochemistry, 62, Pp. 2461-2471. Publisher's Version
(81), YW Liu, NM Marshall, S Yu, W Kim, YG Gao, H Robinson, MJ Nilges, Y Zhang, SY New, and Y Lu. “Structural basis for the effects of phenylalanine on tuning the reduction potential of type 1 copper in azurin.” Inorganic Chemistry, 62, 29, Pp. 11618-11625. Publisher's Version
(80), Y. Jessie Zhang, and Philip A. Cole. “Editorial: Mechanistic Biology.” Current Opinion of Chemical Biology, 74.
(79), Lancaster EB, Johnson WH Jr, LeVieux JA, Hardtke HA, Zhang YJ, and Whitman CP.A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway.” Arch Biochem Biophys., 733, Pp. 109471. Publisher's Version
(78), Blazeck J, Karamitros CS, Ford K, Somody C, Qerqez A, Murray K, Burkholder NT, Marshall N, Sivakumar A, Lu WC, Tan B., Lamb C, Tanno Y, Yemeny MS, Zhang M, McGovern K, Kumada Y, Zhang YJ, Manfredi M, Johnson KA, D'Arcy S, Stone E, and Georgiou G. “Bypassing evolutionary dead-ends and switching the rate-limiting step of a human immunotherapeutic enzyme.” Nature Catalysis, 5, Pp. 952–967. Publisher's Version
(77), Kim W, Chen TY, Cha L, Zhou G, Xing K, Canty NK, Zhang Y *(co-corresponding), and Chang WC. “Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate.” Nature Communication, 13, 5343. Publisher's Version
(76), d’Oelsnitz S, Kim W, Burkholder NT, Javanmardi K, Thyer R, Zhang Y, Alper H, and Ellington AD. “Directed Evolution of a Generalist Biosensor Accelerates Alkaloid Pathway Engineering.” Nature Chemical Biology. Publisher's Version
(74), Lu H, Diaz DJ, Czarnecki NJ, Zhu C, Kim W, Shroff R, Acosta DJ, Alexander B, Cole HO, Zhang YJ, Lynd NA, Ellington AD, and Alper HS. “Machine learning-aided engineering of PET hydrolase for PET depolymerization..” Nature, 604, Pp. 662–667. Publisher's Version
(73), Polyanskaya SA, Moreno RY, Lu B, Feng R, Yao Y, Irani S, Klingbeil O, Yang Z, Wei Y, Demerdash OE, Benjamin LA, Weiss MJ, Zhang YJ, and Vakoc CR. “The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.” Cell Report, 38, 2, Pp. 110233. Publisher's Version
(72), BP Medellin, WJ Yang, S Konduri, J Dong, S Irani, HY Wu, WL Matthews, Z-Y Zhang, D Siegel, and Y Zhang. “Targeted Covalent Inhibition of Small CTD Phosphatase-1 to Promote the Degradation of REST Transcription Factor in Human Cells.” Journal of Medicinal Chemistry , 65, Pp. 507-519. Publisher's Version
(71), F Meng, Z Yu, D Zhang, S. Chen, H Guan, R Zhou, Q Wu, Q Zhang, MK Venkat Ramani, S Liu, B Yang, X-Q Ba, J Zhang, J Huang, X Bai, J Qin, X-H Feng, Ouyang, S, YJ Zhang, T Liang, and P Xu. “Induced phase separatation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity.” Molecular Cell, 81, 20, Pp. 4147-4164. Publisher's Version