Publications

2022
(78), Blazeck J, Karamitros CS, Ford K, Somody C, Qerqez A, Murray K, Burkholder NT, Marshall N, Sivakumar A, Lu WC, Tan B., Lamb C, Tanno Y, Yemeny MS, Zhang M, McGovern K, Kumada Y, Zhang YJ, Manfredi M, Johnson KA, D'Arcy S, Stone E, and Georgiou G. “Bypassing evolutionary dead-ends and switching the rate-limiting step of a human immunotherapeutic enzyme.” Nature Catalysis, 5, Pp. 952–967. Publisher's Version
(77), Kim W, Chen TY, Cha L, Zhou G, Xing K, Canty NK, Zhang Y *(co-corresponding), and Chang WC. “Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate.” Nature Communication, 13, 5343. Publisher's Version
(76), d’Oelsnitz S, Kim W, Burkholder NT, Javanmardi K, Thyer R, Zhang Y, Alper H, and Ellington AD. “Directed Evolution of a Generalist Biosensor Accelerates Alkaloid Pathway Engineering.” Nature Chemical Biology. Publisher's Version
(74), Lu H, Diaz DJ, Czarnecki NJ, Zhu C, Kim W, Shroff R, Acosta DJ, Alexander B, Cole HO, Zhang YJ, Lynd NA, Ellington AD, and Alper HS. “Machine learning-aided engineering of PET hydrolase for PET depolymerization..” Nature, 604, Pp. 662–667. Publisher's Version
(73), Polyanskaya SA, Moreno RY, Lu B, Feng R, Yao Y, Irani S, Klingbeil O, Yang Z, Wei Y, Demerdash OE, Benjamin LA, Weiss MJ, Zhang YJ, and Vakoc CR. “The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.” Cell Report, 38, 2, Pp. 110233. Publisher's Version
(72), BP Medellin, WJ Yang, S Konduri, J Dong, S Irani, HY Wu, WL Matthews, Z-Y Zhang, D Siegel, and Y Zhang. “Targeted Covalent Inhibition of Small CTD Phosphatase-1 to Promote the Degradation of REST Transcription Factor in Human Cells.” Journal of Medicinal Chemistry , 65, Pp. 507-519. Publisher's Version
2021
(71), F Meng, Z Yu, D Zhang, S. Chen, H Guan, R Zhou, Q Wu, Q Zhang, MK Venkat Ramani, S Liu, B Yang, X-Q Ba, J Zhang, J Huang, X Bai, J Qin, X-H Feng, Ouyang, S, YJ Zhang, T Liang, and P Xu. “Induced phase separatation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity.” Molecular Cell, 81, 20, Pp. 4147-4164. Publisher's Version
(70), W Kim, B LeBlanc, WL Matthews, Z-Y Zhang, and YJ Zhang. “Advancements in Chemical Biology Targeting the Kinases and Phosphatases of RNA Polymerase II-mediated Transcription.” Current Opinion in Chemical Biology, 63, Pp. 68-77. Publisher's Version
(69), BM LeBlanc, Moreno, RY, Escobar, E.E., M.K. Venkat Ramani, J.S Brodbelt, and Y Zhang. “What’s all the phos about? Insights into the phosphorylation state of the RNA polymerase II C-terminal domain via mass spectrometry.” Royal Society of Chemistry Chemical Biology, 2, Pp. 1084-1095. Publisher's Version
(67), BJ Bass, Medellin, B.P., J.A. LeVieux, K Erwin, E.B. Lancaster, W.H Johnson, T.S. Kaoud, R.Y. Moreno, de Ruijter, M., P.C. Babbit, Y. J. Zhang, and C.P. Whitman. “Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications.” Biochemistry. Publisher's Version
(65), Zhou R, Wu Q, Wang M, S Irani, Li X, Zhang Q, Meng F, Liu S, Zhang F, Wu L, Lin X, Wang X, Zou J, Song H, Qin J, Liang T, Feng X-H, Zhang YJ, and Xu P. “The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration.” PLoS Biol, 19, 2, Pp. e3001122. Publisher's Version
2020
Ramani M.K.V, Escobar E.E., Irani S., Mayfield JE, Moreno RY, Butalewicz, J., Cotham V.C, Wu H., Tadros M, Brodbelt JS, and Zhang YJ. “Structure Motif for CTD kinase Specificity on RNA polymerase II during Eukaryotic Transcription.” ACS Chemical Biology. Publisher's Version
Aggarwal K, Kuka TP, Banik M, Medellin BP, Ngo CQ, Xie D, Fernandes Y, Dangerfield TL, Ye E, Bouley B, Johnson KA, Zhang YJ, Eberhart JK, and Que EL.Visible Light Mediated Bidirectional Control Over Carbonic Anhydrase Activity in Cells and in Vivo Using Azobenzene Sulfonamides.” J. Am. Chem. Soc. Publisher's Version
Lu W.C., Saha A., Yan W., Garrison K., Pandey R., Irani S., Tiziani S., Zhang Y.J., Georgiou G., DiGiovanni J., and Stone E.Enzyme-Mediated Depletion of Serum L-Met Abrogates Prostate Cancer Growth via Multiple Mechanisms without Evidence of Systemic Toxicity.” PNAS. Publisher's Version
Medellin B.P., Lancaster E.B., Brown S.D., Rakhade S., Babbitt P.C., Whitman C.P., and Zhang Y.J.Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer..” Biochemistry, 59, 16, Pp. 1592-1603. Publisher's Version

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