(70), W Kim, B LeBlanc, WL Matthews, Z-Y Zhang, and YJ Zhang. “Advancements in Chemical Biology Targeting the Kinases and Phosphatases of RNA Polymerase II-mediated Transcription.” Current Opinion in Chemical Biology, 63, Pp. 68-77. Publisher's Version

(69), BM LeBlanc, Moreno, RY, Escobar, E.E., M.K. Venkat Ramani, J.S Brodbelt, and Y Zhang. “What’s all the phos about? Insights into the phosphorylation state of the RNA polymerase II C-terminal domain via mass spectrometry.” Royal Society of Chemistry Chemical Biology, 2, Pp. 1084-1095. Publisher's Version

(68), EE Escobar, MK Venkat Ramani, Y Zhang, and JS Brodbelt. “Parallel Reaction Monitoring of RNA polymerase II Carboxy-terminal Domain Phosphorylation using 193 nm Ultraviolet Photodissociation Mass Spectrometry.” JACS, 143, 22, Pp. 8488-8498. Publisher's Version

(67), BJ Bass, Medellin, B.P., J.A. LeVieux, K Erwin, E.B. Lancaster, W.H Johnson, T.S. Kaoud, R.Y. Moreno, de Ruijter, M., P.C. Babbit, Y. J. Zhang, and C.P. Whitman. “Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications.” Biochemistry. Publisher's Version

(66), MKV Ramani, W Yang, S Irani, and Y Zhang. “Simplicity is the Ultimate Sophistication — Cross-talk of Post-translational Modifications on the RNA Polymerase II.” JMB, 63, Pp. 68-77. Publisher's Version

(65), Zhou R, Wu Q, Wang M, S Irani, Li X, Zhang Q, Meng F, Liu S, Zhang F, Wu L, Lin X, Wang X, Zou J, Song H, Qin J, Liang T, Feng X-H, Zhang YJ, and Xu P. “The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration.” PLoS Biol, 19, 2, Pp. e3001122. Publisher's Version

Gong S, Kirmizialtin S, Chang A, Mayfield JE, Zhang YJ, and Johnson KA. “Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis..” JBC. Publisher's Version

Ramani M.K.V, Escobar E.E., Irani S., Mayfield JE, Moreno RY, Butalewicz, J., Cotham V.C, Wu H., Tadros M, Brodbelt JS, and Zhang YJ. “Structure Motif for CTD kinase Specificity on RNA polymerase II during Eukaryotic Transcription.” ACS Chemical Biology. Publisher's Version

Aggarwal K, Kuka TP, Banik M, Medellin BP, Ngo CQ, Xie D, Fernandes Y, Dangerfield TL, Ye E, Bouley B, Johnson KA, Zhang YJ, Eberhart JK, and Que EL. “Visible Light Mediated Bidirectional Control Over Carbonic Anhydrase Activity in Cells and in Vivo Using Azobenzene Sulfonamides.” J. Am. Chem. Soc. Publisher's Version

Mayfield J.E., Irani S., and Zhang Y.J. “Electrophoretic Mobility Shift Assay of in vitro Phosphorylated RNA Polymerase II Carboxyl-terminal Domain Substrates..” Bioprotocol, 10, 12. Publisher's Version

Lu W.C., Saha A., Yan W., Garrison K., Pandey R., Irani S., Tiziani S., Zhang Y.J., Georgiou G., DiGiovanni J., and Stone E. “Enzyme-Mediated Depletion of Serum L-Met Abrogates Prostate Cancer Growth via Multiple Mechanisms without Evidence of Systemic Toxicity.” PNAS. Publisher's Version

Medellin B.P., Lancaster E.B., Brown S.D., Rakhade S., Babbitt P.C., Whitman C.P., and Zhang Y.J. “Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer..” Biochemistry, 59, 16, Pp. 1592-1603. Publisher's Version

Lee J, Der B.S, Karamitros C.S, Li W, Marshall N.M, Lungu O.I., Miklos A.E., Xu J, Kang T.H., Lee C.H., Tan B., Hughes R.A., Jung S.T., Ippolito G.C., Gray J.J, Zhang YJ, Kuhlman B., Georgiou G.*, and Ellington A.D*. “Rosetta-based Engineering of Thermostabilized Antibody Fragments..” AlChE Journal. Publisher's Version

Burkholder, N.T., Sipe, S.N., Escobar, E.E., Kumar, M., Irani, S, Yang, W., Wu, H., Matthews, W.M., Brodbelt*, J.S., and Y.J Zhang *. “Mapping RNAPII CTD phosphorylation reveals that the identity and modification of seventh heptad residues direct.” ACS Chemical Biology, 14, 10, Pp. 2264-2275. Publisher's Version

Naowarojnan, N., Irani, S, Hu, W., Cheng, R., Zhang, L., Li, X., Chen *, J., YJ* Zhang *, and P Liu *. “Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering to Modulate Its Substrate Selectivity..” ACS Catalysis, 9, 8, Pp. 6955-6961. Publisher's Version

Mayfield, J.E., Irani, S, Escobar, E.E., Zhang, L., Burkholder, N.T., Robinson, M.R., Mehaffey, M.R., Sipe, S.N., Yang, W., Prescott, N., Kathuria, K.R., Liu, Z., J.S Brodbelt, and Y.J Zhang. “Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb..” eLife. Publisher's Version

Irani, S, Sipe, S.N., Yang, W., Burkholder, N.T., Lin, B., Sim, K., Matthews, W.M., Brodbelt, J.S., and Y.J Zhang. “Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate CTD phosphatase during eukaryotic transcription..” JBC, 294, 21, Pp. 8592-8605. Publisher's Version

Baas, B., Medellin, B.P., LeVieux, J.A., de Ruijter, M., Y.J. Zhang *, Brown, S.D., Akiva, E., Babbitt, P.C., and C.P. Whitman *. “Structural, Kinetic, and Mechanistic Analysis of an Asymmetric 4-Oxalocrotonate Tautomerase Trimer..” Biochemistry, 10, 35, Pp. 803– 813. Publisher's Version

Wang, S. A., Ko, Y., Zeng, J., Ren D. Ogasawara Y. Irani S. Zhang Y. Liu H. W Geng, Y., Ren, D., Ogasawara, Y., Irani, S, Y. J. Zhang, and H. W Liu. “Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de novo Purine Biosynthesis..” J. Am. Chem. Soc. , 141, 15, Pp. 6127-6131. Publisher's Version

Burkholder, N.T., Mayfield, J.E., Yu, X., Irani, S, Arce, D.K., Jiang, F., Matthews, W.M., Xue, Y., and Y. J. Zhang. “Phosphatase activity of Small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST)..” JBC, 293, 43, Pp. 16851-16861. Publisher's Version