Medellin B.P., Lancaster E.B., Brown S.D., Rakhade S., Babbitt P.C., Whitman C.P., and Zhang Y.J. “Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer..” Biochemistry, 59, 16, Pp. 1592-1603. Publisher's Version

Lee J, Der B.S, Karamitros C.S, Li W, Marshall N.M, Lungu O.I., Miklos A.E., Xu J, Kang T.H., Lee C.H., Tan B., Hughes R.A., Jung S.T., Ippolito G.C., Gray J.J, Zhang YJ, Kuhlman B., Georgiou G.*, and Ellington A.D*. “Rosetta-based Engineering of Thermostabilized Antibody Fragments..” AlChE Journal. Publisher's Version

Burkholder, N.T., Sipe, S.N., Escobar, E.E., Kumar, M., Irani, S, Yang, W., Wu, H., Matthews, W.M., Brodbelt*, J.S., and Y.J Zhang *. “Mapping RNAPII CTD phosphorylation reveals that the identity and modification of seventh heptad residues direct.” ACS Chemical Biology, 14, 10, Pp. 2264-2275. Publisher's Version

Naowarojnan, N., Irani, S, Hu, W., Cheng, R., Zhang, L., Li, X., Chen *, J., YJ* Zhang *, and P Liu *. “Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering to Modulate Its Substrate Selectivity..” ACS Catalysis, 9, 8, Pp. 6955-6961. Publisher's Version

Mayfield, J.E., Irani, S, Escobar, E.E., Zhang, L., Burkholder, N.T., Robinson, M.R., Mehaffey, M.R., Sipe, S.N., Yang, W., Prescott, N., Kathuria, K.R., Liu, Z., J.S Brodbelt, and Y.J Zhang. “Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb..” eLife. Publisher's Version

Irani, S, Sipe, S.N., Yang, W., Burkholder, N.T., Lin, B., Sim, K., Matthews, W.M., Brodbelt, J.S., and Y.J Zhang. “Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate CTD phosphatase during eukaryotic transcription..” JBC, 294, 21, Pp. 8592-8605. Publisher's Version

Baas, B., Medellin, B.P., LeVieux, J.A., de Ruijter, M., Y.J. Zhang *, Brown, S.D., Akiva, E., Babbitt, P.C., and C.P. Whitman *. “Structural, Kinetic, and Mechanistic Analysis of an Asymmetric 4-Oxalocrotonate Tautomerase Trimer..” Biochemistry, 10, 35, Pp. 803– 813. Publisher's Version

Wang, S. A., Ko, Y., Zeng, J., Ren D. Ogasawara Y. Irani S. Zhang Y. Liu H. W Geng, Y., Ren, D., Ogasawara, Y., Irani, S, Y. J. Zhang, and H. W Liu. “Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de novo Purine Biosynthesis..” J. Am. Chem. Soc. , 141, 15, Pp. 6127-6131. Publisher's Version

Burkholder, N.T., Mayfield, J.E., Yu, X., Irani, S, Arce, D.K., Jiang, F., Matthews, W.M., Xue, Y., and Y. J. Zhang. “Phosphatase activity of Small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST)..” JBC, 293, 43, Pp. 16851-16861. Publisher's Version

LeVieux, J.A., Medellin, B.P., Johnson, W.H. Jr., Erwin, K., Li, X., Johnson, W.H. Jr., YJ. Zhang *, and C.P* Whitman. “Structural Characterization of the Hydratase-Aldolases, NahE, and PhdJ: Implications for the Specificity, Catalysis, and N-Acetylneuraminate Lyase Subgroup of the Aldolase Superfamily..” Biochemistry, 57, 25, Pp. 3524-3536 . Publisher's Version

Irani, S, Naowarojna, N., Tang, Y., Kathuria, K.R., Wang, S. A., Dhembi, A., Lee, N., Yan, W., Lyu, H., Costello, C.E., P. Liu, and Y. J. Zhang. “Snapshots of C-S cleavage in Egt2 reveals substrate specificity and reaction mechanism..” Cell Chemical Biology, 25, 5, Pp. 519-529.e4. . Publisher's Version

Burkholder, N.T., Medellin, B.P., Irani, S, Matthews, W.M., Showalter, S.A., and Y. J. Zhang. “Chemical tools for studying the impact of cis/trans prolyl isomerization on RNA polymerase II CTD phosphatase activity and specificity..” In Methods in Enzymology, 607: Pp. 269-297.

Stack, T.M.M., Li, X., Johnson, W.H. Jr., YJ Zhang, and C.P. Whitman. “Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates..” Biochemistry, 57, 6, Pp. 1012-1021. Publisher's Version

Davidson, R., Baas, B., Akiva, E., Holliday, G.L., Polacco, B.J., LeVieux, J.A., Pullara, C.R., YJ Zhang, C.P Whitman, and P.C. Babbitt. “A Global View of Structure-Function Relationships in the Tautomerase Superfamily..” JBC, 293, 7, Pp. 2342-2357. Publisher's Version

LeVieux, J.A., Baas, B., Kaoud, T.S., Davidson, R., Babbitt, P.C., YJ Zhang, and C.P. Whitman. “Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily..” Arch. Biophy. Biochem. , 636, Pp. 50-56. . Publisher's Version

Lee, N., Romain, G., Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee J., Triplett, K., Donkor, M., Lungu, O.I., A. Lux, Marshall, N., Lindorfer, M.A., Goff, O.R., Balbino, B., Kang, T.H., Tanno, H., G Delidaki, Alford, C., R.P. Taylor, Nimmerjahn, F., Varadarajan, N., Bruhns, P., Y. J. Zhang, and G. Georgiou. “IgG Fc Domains that bind C1q but not effector Fcgamma receptors delineate that significance of complement-mediated cell cytotoxicity and phagocytosis in antibody function..” Nature Immunology. , 18, 8, Pp. 889-898. Publisher's Version

Gibbs, E.B., Y Lu, B Portz, M. J. Fisher, Medellin, B.P., Laremore, T.N., Zhang, L., Gilmour, D.S., and S.A Showalter. “Phosphorylation Induces Sequence-Specific Conformational Switches in the RNA Polymerase II C-Terminal Domain..” Nature Communications. , 8, Pp. 15233. Publisher's Version

Portz, B., Lu, Gibbs, E.B., Mayfield, J.E., Mehaffey, M.R., Zhang, L., Brodbelt, J.S., Showalter, S.A., and D.S. Gilmour. “Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain..” Nature Communications., 8, Pp. 15231. Publisher's Version

Yan, W., Georgiou, G., Stone, E., and Y. J. Zhang. “Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site..” Biochemistry, 56, 6, Pp. 876-885. Publisher's Version

Cramer, S., Saha, A., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., S. Alters, Johnson, W.H. Jr., Zhang, L., DiGiovanni, J., Georgiou, G., and E. Stone. “Systemic depletion of serum L-Cyst(e)ine with an engineered human enzyme induces the production of reactive oxygen species and suppresses tumor growth in mice..” Nature Medicine, 23, 1, Pp. 120-127. Publisher's Version