Publications

2017
Lee, N., Romain, G., Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee J., Triplett, K., Donkor, M., Lungu, O.I., A. Lux, Marshall, N., Lindorfer, M.A., Goff, O.R., Balbino, B., Kang, T.H., Tanno, H., G Delidaki, Alford, C., R.P. Taylor, Nimmerjahn, F., Varadarajan, N., Bruhns, P., Y. J. Zhang, and G. Georgiou. “IgG Fc Domains that bind C1q but not effector Fcgamma receptors delineate that significance of complement-mediated cell cytotoxicity and phagocytosis in antibody function..” Nature Immunology. , 18, 8, Pp. 889-898. Publisher's Version
Gibbs, E.B., Y Lu, B Portz, M. J. Fisher, Medellin, B.P., Laremore, T.N., Zhang, L., Gilmour, D.S., and S.A Showalter. “Phosphorylation Induces Sequence-Specific Conformational Switches in the RNA Polymerase II C-Terminal Domain..” Nature Communications. , 8, Pp. 15233. Publisher's Version
Portz, B., Lu, Gibbs, E.B., Mayfield, J.E., Mehaffey, M.R., Zhang, L., Brodbelt, J.S., Showalter, S.A., and D.S. Gilmour. “Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain..” Nature Communications., 8, Pp. 15231. Publisher's Version
2016
Cramer, S., Saha, A., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., S. Alters, Johnson, W.H. Jr., Zhang, L., DiGiovanni, J., Georgiou, G., and E. Stone. “Systemic depletion of serum L-Cyst(e)ine with an engineered human enzyme induces the production of reactive oxygen species and suppresses tumor growth in mice..” Nature Medicine, 23, 1, Pp. 120-127. Publisher's Version
Mayfield, J.E., Robinson, M.R., Cotham, V.C., Irani, S, Matthews, W.M., Ram, A., Gilmour, D.S., Cannon, J.R., YJ Zhang *, and J.S Brodbelt *. “Mapping the phosphorylation pattern of Drosophila RNA polymerase II carboxyl-terminal domain using ultraviolet photodissociation mass spectrometry..” ACS Chemical Biology, 12, 1, Pp. 153-162. Publisher's Version
Mayfield, J.E., Burkholder, N.T., and Y. J. Zhang. “Dephosphorylating eukaryotic RNA polymerase II..” BBA Proteins Proteom. , 1864, 4, Pp. 372-387. Publisher's Version
Irani, S, Yogesha, S.D., Mayfield, J.E., Zhang, L., Zhang, L., Matthews, W.M., Nie, G., Prescott, N., and Y. Zhang. “Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase..” Science Signaling, 9, Pp. 417. Publisher's Version
Li, X., Irani. S., Crutchfield, A., Hodge, K., Matthews, W.M., Patel, P., Zhang *, YJ, and E. Stone *. “Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages..” Biochemistry, 55, 6, Pp. 960-969. Publisher's Version
LeVieux, J.A., Johnson, W.H. Jr., Erwin, K., Li, X., Y. J. Zhang, and C.P. Whitman. “The bacterial catabolism of polycyclic aromatic hydrocarbons: Characterization of three hydratase-aldolase-catalyzed reactions..” Perspective in Science., 99, Pp. 33-41. Publisher's Version
2015
Mayfield, J.E., Fan, S., Wei, S., Zhang, L., Li, X., Ellington, A.D., Etzkorn, F.A., and Y. J. Zhang. “Chemical tools to decipher regulation of phosphatases by proline isomerization on eukaryotic RNA polymerase II..” ACS Chemical Biology, 10, 10, Pp. 2405-14. Publisher's Version
Wei, S., Kozono, S., Kats, L., Nechama, M., Li, X., Guarnerio, J., Luo, M., You, M.H., Y. Yao, Kondo, A., Hu, W., Bozkurt, G., Moerke, N., Cao, S., Reschke, M., Chen, J.*, Rego, E.M., Lo-Coco, F., L.C. Cantley, Lee, N., Wu, H., YJ Zhang, Pandolfi, P.P., Zhou, X.Z., and K.P. Lu. “Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer..” Nature Medicine, 21, Pp. 457-466. Publisher's Version
Chen, J.*, Li, X., Sultana, R., You, M.H., Kondo, A., Shahpasand, K., Kim, B., Luo, M., M Nechama, Lin, B., Yao, Y., Lee, N., Zhou, X.Z., Swomley, A., D Butterfield*, YJ Zhang *, and KP Lu*. “Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease..” Neurobiol. Dis. , 76, Pp. 13-23. Publisher's Version
He, Y., Guo, Y., Yu, X., Wu, H., Gunawan, A.M., YJ Zhang, Dixon, J.E., and Z.Y. Zhang. “A potent and selective inhibitor for the UBLCP1 proteasome phosphatase..” Bioorg. Med. Chem., 23, 12, Pp. 2798-2809. . Publisher's Version

Pages