Zhang Lab at UT Austin

Welcome to Zhang Lab!

Mission

Free thinking

Ethical practice

Team work

Enjoy science

Austin

Recent Publications

Structural basis for the effects of phenylalanine on tuning the reduction potential of type 1 copper in azurin
Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate
Bypassing evolutionary dead-ends and switching the rate-limiting step of a human immunotherapeutic enzyme
Kinetic, Inhibition, and Structural Characterization of a Malonate Semialdehyde Decarboxylase Homolog from Calothrix sp. PCC 6303: A Gateway to the non-Pro1 Tautomerase Superfamily Members
Directed Evolution of a Generalist Biosensor Accelerates Alkaloid Pathway Engineering

Welcome Statement

Phantom of opera

The Zhang Lab is dedicated to unraveling the fascinating realm of post-translational modifications and its effects on eukaryotic transcription. We focus on phosphorylation utilizing cutting-edge approaches that merge structural biology, biophysics, and Nextgen sequencing. Our aim is to shed light on the complexities of kinases, phosphatases, and transcription factors involving in diseases like glioblastoma and neurodegenerative diseases. Moreover, we believe that through our structural understanding, we can make a real impact by designing small molecules or proteins that can modulate enzymatic activities. Join us in this meaningful quest for knowledge.